The role of Janus Kinase 3 in CD4+ T Cell Homeostasis and Function: A Dissertation
نویسندگان
چکیده
This dissertation addresses the role for Janus Kinase 3 (Jak3) in CD4+ T cell homeostasis and function. Jak3 is a protein tyrosine kinase whose activity is essential for signals mediated by the yc dependent cytokines IL-2, -4, -7,-9,-15, and -21. Previous data have demonstrated that peripheral CD4+ T cells from Jak3-deficient mice have a memory phenotype and are functionally impaired in both proliferative and IL-2 responses in vitro. Interestingly, Jak3/yc activity has been previously shown to play a role in the prevention of T
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